Background: Atypical fibroxanthoma (AFX) represents an uncommon skin tumor typically occurring on sun‐damaged skin of the elderly. Histopathologic variants include spindled, clear cell, osteoid, osteoclastic, chondroid, pigmented, granular cell and myxoid lesions.

cal fibroxanthoma since ultrastructure studies represent the most valid basis on which a correct diagnosis can be made. CU~CCT 40:736-743, 1977. T HE TERMINOLOGY OF ATYPICAL FIBROXAN- thoma (AFX) has been used by Helwig at the Armed Forces Institute of Pathology (AFIP) since at least 1956, and he subsequently de-

The tumor is … Case for diagnosis. Atypical fibroxanthoma. April 2019; Anais Brasileiros de Dermatologia 94(2):239-241; DOI: 10.1590/abd1806-4841.20197330 2017-10-20 Atypical fibroxanthoma (AFX) has been considered as the non-infiltrating precursor lesion of pleomorphic dermal sarcoma (PDS), which shows an aggressive clinical behavior, because of its extensive invasion of the deeper skin layers. Although these two tumors may represent two stages of the same disease, it can be difficult to differentiate between them, because of their similar clinical and Department of Anatomic Pathology, Azienda Ospedaliero‐Universitaria di Modena, Italy. Correspondence .

COMMENT: The diagnosis of atypical fibroxanthoma (AFX) is favoured. The main differential diagnosis is pleomorphic undifferentiated sarcoma. The extent of the lesion cannot be determined, as it is present at the deep margin. This lesion should be re-excised, as it could represent an aggressive malignancy.

2016-04-01 · Atypical fibroxanthoma (AFX) has been a topic for debate since the 1960s, when Helwig (1) coined its present name. He later published in 1973 a study (2) of 140 cases describing its pathologic features.

Although these entities are not new in the dermatopathology world, the presence of a collision tumour involving these two entities is extremely rare and should be considered in diagnosing histologically challenging skin lesions. Pathology Atypical fibroxanthomas are fibrohistiocytic skin tumors with a wide range of appearances on histological examinations and a certain histological similarity to squamous cell carcinoma. The diagnosis requires skin biopsy with careful evaluation to differentiate it from other skin tumors, BACKGROUND: Atypical fibroxanthoma is a rare mesenchymal tumor of the head and neck region. METHODS: We analyzed the files of 3 large dermatology hospitals from the years 2001 to 2013 in southeast Germany.

Atypical fibroxanthoma (AFX) is a cutaneous neoplasm of uncertain histogenesis, which is typically found on sun-damaged skin of the elderly, particularly the head

Leiomyosarcoma : Usually positive for smooth muscle markers, such as smooth muscle myosin and desmin. Metastatic carcinoma : Smooth muscle tumor. Nerve sheath tumor. Pleomorphic malignant fibrous histiocytoma. Nearly always involves sun damaged skin of the elderly. May also occur in irradiated areas. Involves dermis.

Atypical fibroxanthoma (AFX) is a pleomorphic, predominantly dermal mesenchymal tumor found in actinic-damaged cutaneous sites in older patients or involving the superficial soft tissues of the extremities and trunk in younger patients. From: Modern Surgical Pathology (Second Edition), 2009. Related terms: Neoplasm Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) share clinical, pathological, immunohistochemical and molecular features, though PDS is associated with a more aggressive behavior. 2017-10-20 · Atypical fibroxanthoma is an uncommon cutaneous tumor that often occurs on the head and neck region of elderly patients with extensive ultraviolet sunlight exposure [1, 3]. The lesion may itself present as a solitary or multifocal red or pink dome-shaped nodule with high vascularity [2, 4]. Background: Atypical fibroxanthoma (AFX) represents an uncommon skin tumor typically occurring on sun‐damaged skin of the elderly.
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The pathogenesis of these tumors is not well understood. We report two rare examples of dermal fibrohistiocytic stromal tumors: one case of atypical fibrous histiocytoma (AFH) and another one of atypical fibroxanthoma (AFX), which can be confused in surgical pathology diagnosis with high-grade malignant neoplasm. Histologically, a proliferation of mononuc … Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation. Clinically, lesions usually are suggestive of malignancy because they arise rapidly (over just a few weeks or months) in skin in which other skin Microscopic diagnosis was that of a collision lesion involving atypical fibroxanthoma and basal cell carcinoma. This is a very rare pathological diagnosis and should be considered by pathologists when diagnosing challenging skin lesions.

The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. Pathology of atypical fibroxanthoma Atypical fibroxanthoma is a dermally based tumour of uncertain histogenesis which is characterised by its pleomorphic appearance but generally low-grade clinical behaviour. It occurs in the older age group, usually in the setting of marked solar elastosis on the head and neck. Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior.
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Köp Dermatopathology, An Issue of Surgical Pathology Clinics av Thomas Brenn Spitz tumors; Atypical fibroxanthoma; Cutaneous malignant peripheral nerve

Prolonged sun exposure, actinic damaged, history of previous neoplasms and immunosuppressant are considered the most important risks factors. Subcutaneous extension of these tumors is related to a more aggressive biology. 1988-12-01 Posts about Atypical fibroxanthoma (AFX) written by dpsarma. Dr Sarma's Dermpath & other Pathology topics Dermatopathology cases from my 45 years of pathology practice and other non … Background: Atypical fibroxanthoma (AFX) represents an uncommon skin tumor typically occurring on sun‐damaged skin of the elderly. Histopathologic variants include spindled, clear cell, osteoid, osteoclastic, chondroid, pigmented, granular cell and myxoid lesions.